Lee W. Riley, MD, Robert S Remis MD, MPH, Steven D Helgerson, MD,
MPH, Harry B McGee, MPH, Joy G Wells, MS, Betty R Davis, MS,
Richard J Herbert MD, Ellen S Olcott, RN, Linda M Johnson, RN, MS,
Nancy T Hargrtett, PhD, Paul A Blake, MD, MPH and Mithchell L
Cohen MD. Abstract:

1982年に米国のオレゴン州とミシガ州ンでマクドナルドの商品の中から O157:H7が発見されました。。。
In 1982, in Oregon and Michigan in the USA, O157:H7 existed in McDonald's food...

We investigated two outbreaks of an unusual gastrointestinal illness that affected at least 47 people in Oregon and Michigan in February through March and May through June 1982. The illness was characterized by severe crampy abdominal pain, initially watery diarrhoea followed by grossly bloody diarrhoea, and little or no fever. It was associated with eating at restaurants belonging to the same fast food restaurant chain in Oregon (P less than 0.005) and Michigan (P=0.0005) (ie. McDonald's) and with eating any of three sandwiches containing three ingredients in common (beef patty, rehydrated onions and pickles). Stool cultures did not yield previously recognized pathogens. However a rare Escherichia coli serotype, 0157:H7 that was not invasive or toxigenic by standard tests was isolated from 9 of 12 stools collected within four days of onset of illness in both outbreaks combined, and from a beef patty from a suspected lot of meat in Michigan. The only known previous isolation of this serotype was from a sporadic case of haemorrhagic colitis in 1975. This report describes a clinically distinctive gastrointestinal illness associated with E. coli 0157:h7, apparently transmitted by undercooked meat (N Engl J Med 1983; 308:681-5).